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Effects of Cannabis on Impulsivity: A Systematic Review of Neuroimaging Findings

Wrege, Johannes and Schmidt, André and Walter, Anna and Smieskova, Renata and Bendfeldt, Kerstin and Radue, Ernst-Wilhelm and Lang, Undine E. and Borgwardt, Stefan. (2014) Effects of Cannabis on Impulsivity: A Systematic Review of Neuroimaging Findings. Current Pharmaceutical Design, 20 (13). pp. 2126-2137.

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Official URL: https://edoc.unibas.ch/63084/

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Abstract

We conducted a systematic review to assess the evidence for specific effects of cannabis on impulsivity, disinhibition and motor control. The review had a specific focus on neuroimaging findings associated with acute and chronic use of the drug and covers literature published up until May 2012. Seventeen studies were identified, of which 13 met the inclusion criteria; three studies investigated acute effects of cannabis (1 fMRI, 2 PET), while six studies investigated non-acute functional effects (4 fMRI, 2 PET), and four studies investigated structural alterations. Functional imaging studies of impulsivity studies suggest that prefrontal blood flow is lower in chronic cannabis users than in controls. Studies of acute administration of THC or marijuana report increased brain metabolism in several brain regions during impulsivity tasks. Structural imaging studies of cannabis users found differences in reduced prefrontal volumes and white matter integrity that might mediate the abnormal impulsivity and mood observed in marijuana users. To address the question whether impulsivity as a trait precedes cannabis consumption or whether cannabis aggravates impulsivity and discontinuation of usage more longitudinal study designs are warranted.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
UniBasel Contributors:Schmidt, André
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Bentham Science Publishers
ISSN:1381-6128
e-ISSN:1873-4286
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 Aug 2018 15:56
Deposited On:28 Aug 2018 15:56

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