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Modulation of motivational salience processing during the early stages of psychosis

Smieskova, Renata and Roiser, Jonathan P. and Chaddock, Christopher A. and Schmidt, André and Harrisberger, Fabienne and Bendfeldt, Kerstin and Simon, Andor and Walter, Anna and Fusar-Poli, Paolo and McGuire, Philip K. and Lang, Undine E. and Riecher-Rössler, Anita and Borgwardt, Stefan. (2015) Modulation of motivational salience processing during the early stages of psychosis. Schizophrenia Research, 166 (1-3). pp. 17-23.

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Official URL: https://edoc.unibas.ch/63066/

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Abstract

BACKGROUND: Deficits in motivational salience processing have been related to psychotic symptoms and disturbances in dopaminergic neurotransmission. We aimed at exploring changes in salience processing and brain activity during different stages of psychosis and antipsychotic medication effect.
METHODS: We used fMRI during the Salience Attribution Task to investigate hemodynamic differences between 19 healthy controls (HCs), 34 at-risk mental state (ARMS) individuals and 29 individuals with first-episode psychosis (FEP), including a subgroup of 17 FEP without antipsychotic medication (FEP-UM) and 12 FEP with antipsychotic medication (FEP-M). Motivational salience processing was operationalized by brain activity in response to high-probability rewarding cues (adaptive salience) and in response to low-probability rewarding cues (aberrant salience).
RESULTS: Behaviorally, adaptive salience response was not accelerated in FEP, although they correctly distinguished between trials with low and high reward probability. In comparison to HC, ARMS exhibited a lower hemodynamic response during adaptive salience in the right inferior parietal lobule and FEP-UM in the left dorsal cingulate gyrus. The FEP-M group exhibited a lower adaptive salience response than HC in the right insula and than ARMS in the anterior cingulate gyrus. In unmedicated individuals, the severity of hallucinations and delusions correlated negatively with the insular- and anterior cingulate hemodynamic response during adaptive salience. We found no differences in aberrant salience processing associated with behavior or medication.
CONCLUSION: The changes in adaptive motivational salience processing during psychosis development reveal neurofunctional abnormalities in the somatosensory and premotor cortex. Antipsychotic medication seems to modify hemodynamic responses in the anterior cingulate and insula.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
UniBasel Contributors:Schmidt, André and Harrisberger, Fabienne and Riecher-Rössler, Anita
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0920-9964
e-ISSN:1573-2509
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:21 Aug 2019 13:12
Deposited On:28 Aug 2018 15:47

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