Structural Network Disorganization in Subjects at Clinical High Risk for Psychosis

Schmidt, André and Crossley, Nicolas A. and Harrisberger, Fabienne and Smieskova, Renata and Lenz, Claudia and Riecher-Rössler, Anita and Lang, Undine E. and McGuire, Philip and Fusar-Poli, Paolo and Borgwardt, Stefan. (2016) Structural Network Disorganization in Subjects at Clinical High Risk for Psychosis. Schizophrenia Bulletin, 43 (3). pp. 583-591.

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Previous network studies in chronic schizophrenia patients revealed impaired structural organization of the brain's rich-club members, a set of highly interconnected hub regions that play an important integrative role for global brain communication. Moreover, impaired rich-club connectivity has also been found in unaffected siblings of schizophrenia patients, suggesting that abnormal rich-club connectivity is related to familiar, possibly reflecting genetic, vulnerability for schizophrenia. However, no study has yet investigated whether structural rich-club organization is also impaired in individuals with a clinical risk syndrome for psychosis. Diffusion tensor imaging and probabilistic tractography was used to construct structural whole-brain networks in 24 healthy controls and 24 subjects with an at-risk mental state (ARMS). Graph theory was applied to quantify the structural rich-club organization and global network properties. ARMS subjects revealed a significantly altered structural rich-club organization compared with the control group. The disruption of rich-club organization was associated with the severity of negative psychotic symptoms and led to an elevated level of modularity in ARMS subjects. This study shows that abnormal structural rich-club organization is already evident in clinical high-risk subjects for psychosis and further demonstrates the impact of rich-club disorganization on global network communication. Together with previous evidence in chronic schizophrenia patients and unaffected siblings, our findings suggest that abnormal structural rich-club organization may reflect an endophenotypic marker of psychosis.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
UniBasel Contributors:Riecher-Rössler, Anita and Borgwardt, Stefan and Lenz, Claudia and Harrisberger, Fabienne and Schmidt, André
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Oxford Academic
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Aug 2018 15:34
Deposited On:09 Aug 2018 15:33

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