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Monoclonal Antibodies and Recombinant Immunoglobulins for the Treatment of Multiple Sclerosis

Gensicke, H. and Leppert, D. and Yaldizli, O. and Lindberg, R. L. and Mehling, M. and Kappos, L. and Kuhle, J.. (2012) Monoclonal Antibodies and Recombinant Immunoglobulins for the Treatment of Multiple Sclerosis. CNS Drugs, 26 (1). pp. 11-37.

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Official URL: https://edoc.unibas.ch/63045/

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Abstract

Multiple sclerosis (MS) is an inflammatory and degenerative disease leading to demyelination and axonal damage in the CNS. Autoimmunity plays a central role in MS pathogenesis. Per definition, monoclonal antibodies are recombinant biological compounds with a well defined target, thus carrying the promise of targeting pathogenic cells or molecules with high specificity, avoiding undesired off-target effects. Natalizumab was the first monoclonal antibody to be approved for the treatment of MS. Several other monoclonal antibodies are in development and have demonstrated promising efficacy in phase II studies. They can be categorized according to their mode of action into compounds targeting (i) leukocyte migration into the CNS (natalizumab); (ii) cytolytic antibodies (rituximab, ocrelizumab, ofatumumab, alemtuzumab); or (iii) antibodies and recombinant proteins targeting cytokines and chemokines and their receptors (daclizumab, ustekinumab, atacicept, tabalumab [Ly-2127399], secukinumab [AIN457]). In this review, we discuss the specific molecular targets, clinical efficacy and safety of these compounds and discuss criteria to anticipate the position of monoclonal antibodies in the diversifying armamentarium of MS therapy in the coming years.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Clinical Neuroimmunology (Derfuss/Lindberg)
UniBasel Contributors:Lindberg Gasser, Raija L.P. and Mehling, Matthias and Kappos, Ludwig
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer
ISSN:1172-7047
e-ISSN:1179-1934
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:12 Apr 2018 13:43
Deposited On:12 Apr 2018 09:56

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