Computational neuropsychiatry - schizophrenia as a cognitive brain network disorder

Dauvermann, Maria R. and Whalley, Heather C. and Schmidt, André and Lee, Graham L. and Romaniuk, Liana and Roberts, Neil and Johnstone, Eve C. and Lawrie, Stephen M. and Moorhead, Thomas W. J.. (2014) Computational neuropsychiatry - schizophrenia as a cognitive brain network disorder. Frontiers in Psychiatry, 5. p. 30.

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Computational modeling of functional brain networks in fMRI data has advanced the understanding of higher cognitive function. It is hypothesized that functional networks mediating higher cognitive processes are disrupted in people with schizophrenia. In this article, we review studies that applied measures of functional and effective connectivity to fMRI data during cognitive tasks, in particular working memory fMRI studies. We provide a conceptual summary of the main findings in fMRI data and their relationship with neurotransmitter systems, which are known to be altered in individuals with schizophrenia. We consider possible developments in computational neuropsychiatry, which are likely to further our understanding of how key functional networks are altered in schizophrenia.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
UniBasel Contributors:Schmidt, André
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Frontiers Research Foundation
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:25 Aug 2018 12:55
Deposited On:25 Aug 2018 12:55

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