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Abnormal Functional Integration of Thalamic Low Frequency Oscillation in the BOLD Signal After Acute Heroin Treatment

Denier, Niklaus and Schmidt, André and Gerber, Hana and Vogel, Marc and Huber, Christian G. and Lang, Undine E. and Riecher-Rossler, Anita and Wiesbeck, Gerhard A. and Radue, Ernst-Wilhelm and Walter, Marc and Borgwardt, Stefan. (2015) Abnormal Functional Integration of Thalamic Low Frequency Oscillation in the BOLD Signal After Acute Heroin Treatment. Human Brain Mapping, 36 (12). pp. 5287-5300.

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Official URL: https://edoc.unibas.ch/62998/

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Abstract

Heroin addiction is a severe relapsing brain disorder associated with impaired cognitive control, including deficits in attention allocation. The thalamus has a high density of opiate receptors and is critically involved in orchestrating cortical activity during cognitive control. However, there have been no studies on how acute heroin treatment modulates thalamic activity. In a cross-over, double-blind, vehicle-controlled study, 29 heroin-maintained outpatients were studied after heroin and placebo administration, while 20 healthy controls were included for the placebo condition only. Resting-state functional magnetic resonance imaging was used to analyze functional integration of the thalamus by three different resting state analysis techniques. Thalamocortical functional connectivity (FC) was analyzed by seed-based correlation, while intrinsic thalamic oscillation was assessed by analysis of regional homogeneity (ReHo) and the fractional amplitude of low frequency fluctuations (fALFF). Relative to the placebo treatment and healthy controls, acute heroin administration reduced thalamocortical FC to cortical regions, including the frontal cortex, while the reductions in FC to the mediofrontal cortex, orbitofrontal cortex, and frontal pole were positively correlated with the plasma level of morphine, the main psychoactive metabolite of heroin. Furthermore, heroin treatment was associated with increased thalamic ReHo and fALFF values, whereas fALFF following heroin exposure correlated negatively with scores of attentional control. The heroin-associated increase in fALFF was mainly dominated by slow-4 (0.027-0.073 Hz) oscillations. Our findings show that there are acute effects of heroin within the thalamocortical system and may shed new light on the role of the thalamus in cognitive control in heroin addiction. Future research is needed to determine the underlying physiological mechanisms and their role in heroin addiction.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
UniBasel Contributors:Schmidt, André and Riecher-Rössler, Anita
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley-Blackwell - STM
ISSN:1065-9471
e-ISSN:1097-0193
Note:Publication type according to Uni Basel Research Database: Journal article -- This is the peer reviewed version of the following article: Abnormal Functional Integration of Thalamic Low Frequency Oscillation in the BOLD Signal After Acute Heroin Treatment, which has been published in final form at [see DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Language:English
Identification Number:
Last Modified:28 Mar 2019 14:51
Deposited On:25 Aug 2018 12:42

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