Relating functional changes during hand movement to clinical parameters in patients with multiple sclerosis in a multi-centre fMRI study

Wegner, Christiane and Filippi, M. and Korteweg, Theodoor and Beckmann, Christian F. and Ciccarelli, O. and De Stefano, Nicola and Enzinger, Christian and Fazekas, F. and Agosta, Federica and Gass, Achim and Hirsch, Jochen G. and Johansen-Berg, H. and Kappos, Ludwig and Barkhof, Frederik and Polman, C. and Mancini, L. and Manfredonia, Francesco and Marino, Silvia and Miller, D. H. and Montalban, X. and Palace, Jacqueline and Rocca, Mara A. and Ropele, S. and Rovira, Alex and Smith, Suzi and Thompson, A. and Thornton, John S. and Yousry, T. and Matthews, Paul M.. (2008) Relating functional changes during hand movement to clinical parameters in patients with multiple sclerosis in a multi-centre fMRI study. European journal of neurology, 15 (2). pp. 113-122.

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Official URL: https://edoc.unibas.ch/62984/

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We performed a prospective multi-centre study using functional magnetic resonance imaging (fMRI) to better characterize the relationships between clinical expression and brain function in patients with multiple sclerosis (MS) at eight European sites (56 MS patients and 60 age-matched, healthy controls). Patients showed greater task-related activation bilaterally in brain regions including the pre- and post-central, inferior and superior frontal, cingulate and superior temporal gyri and insula (P > 0.05, all statistics corrected for multiple comparisons). Both patients and healthy controls showed greater brain activation with increasing age in the ipsilateral pre-central and inferior frontal gyri (P > 0.05). Patients, but not controls, showed greater brain activation in the anterior cingulate gyrus and the bilateral ventral striatum (P > 0.05) with less hand dexterity. An interaction between functional activation changes in MS and age was found. This large fMRI study over a broadly selected MS patient population confirms that movement for patients demands significantly greater cognitive 'resource allocation' and suggests age-related differences in brain responses to the disease. These observations add to evidence that brain functional responses (including potentially adaptive brain plasticity) contribute to modulation of clinical expression of MS pathology and demonstrate the feasibility of a multi-site functional MRI study of MS.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Neurologie > Neuroimmunologie (Kappos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Neurologie > Neuroimmunologie (Kappos)
UniBasel Contributors:Kappos, Ludwig
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Aug 2020 13:22
Deposited On:06 Aug 2020 13:22

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