edoc

A fulminant malignant hyperthermia episode in a patient with ryanodine receptor gene mutation p.Tyr522Ser

Girard, Thierry and Suhner, Markus and Levano, Soledad and Singer, Martine and Zollinger, Andreas and Hofer, Christoph K.. (2008) A fulminant malignant hyperthermia episode in a patient with ryanodine receptor gene mutation p.Tyr522Ser. Anesthesia and Analgesia, 107 (6). pp. 1953-1955.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/62954/

Downloads: Statistics Overview

Abstract

A 37-yr-old patient scheduled for elective bursectomy developed fulminant malignant hyperthermia (MH) under sevoflurane anesthesia. The first sign was a dramatic increase in end-tidal CO(2). Symptomatic and specific therapy was rapidly instituted. Postoperative rhabdomyolysis was treated with veno-venous hemofiltration. The patient rejected open muscle biopsy for in vitro contracture testing. Therefore, molecular testing was performed. An infrequent MH causative mutation was identified on the ryanodine receptor gene. This case report confirms the causative nature of this mutation. It also shows that molecular genetic investigation may be as appropriate as in vitro contracture testing to confirm the diagnosis after a clinical episode of MH.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Perioperative Patient Safety (Girard/Treves)
UniBasel Contributors:Girard, Thierry
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott, Williams & Wilkins
ISSN:0003-2999
e-ISSN:1526-7598
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:06 Aug 2020 12:16
Deposited On:06 Aug 2020 12:16

Repository Staff Only: item control page