Müller, Philipp and Martin, Kea Simone and Theurich, Sebastian and von Bergwelt-Baildon, Michael and Zippelius, Alfred. (2014) Cancer chemotherapy agents target intratumoral dendritic cells to potentiate antitumor immunity. Oncoimmunology, 3 (8). e954460.
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Official URL: https://edoc.unibas.ch/62548/
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Abstract
Cytotoxic drugs capable of killing cancer cells in conjunction with targeted conversion of tumor resident, tolerogenic dendritic cells (DCs) into efficient antigen presenting cells (APCs) are highly complementary therapeutic routes to boost antitumor immunity. Our data suggest that the microtubule-depolymerizing compounds Dolastatin 10 and Ansamitocin P3 may serve as prototypes for a class of agents that display this binary mode of action.
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Cancer Immunology and Biology (Zippelius/Rochlitz) |
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| UniBasel Contributors: | Zippelius, Alfred |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Taylor & Francis |
| ISSN: | 2162-4011 |
| e-ISSN: | 2162-402X |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Related URLs: | |
| Identification Number: |
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| Last Modified: | 04 Aug 2020 14:53 |
| Deposited On: | 04 Aug 2020 14:53 |
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