Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate

Wu, X. and Briseno, C. G. and Grajales-Reyes, G. E. and Haldar, M. and Iwata, A. and Kretzer, N. M. and Kc, W. and Tussiwand, R. and Higashi, Y. and Murphy, T. L. and Murphy, K. M.. (2016) Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate. Proc Natl Acad Sci U S A, 113 (51). pp. 14775-14780.

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Official URL: https://edoc.unibas.ch/62511/

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Dendritic cells (DCs) and monocytes develop from a series of bone-marrow-resident progenitors in which lineage potential is regulated by distinct transcription factors. Zeb2 is an E-box-binding protein associated with epithelial-mesenchymal transition and is widely expressed among hematopoietic lineages. Previously, we observed that Zeb2 expression is differentially regulated in progenitors committed to classical DC (cDC) subsets in vivo. Using systems for inducible gene deletion, we uncover a requirement for Zeb2 in the development of Ly-6Chi monocytes but not neutrophils, and we show a corresponding requirement for Zeb2 in expression of the M-CSF receptor in the bone marrow. In addition, we confirm a requirement for Zeb2 in development of plasmacytoid DCs but find that Zeb2 is not required for cDC2 development. Instead, Zeb2 may act to repress cDC1 progenitor specification in the context of inflammatory signals.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Immune Regulation (Tussiwand)
UniBasel Contributors:Tussiwand, Roxane
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1091-6490 (Electronic)0027-8424 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:21 May 2020 13:58
Deposited On:21 May 2020 13:58

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