Transcriptional Control of Dendritic Cell Development

Murphy, T. L. and Grajales-Reyes, G. E. and Wu, X. and Tussiwand, R. and Briseno, C. G. and Iwata, A. and Kretzer, N. M. and Durai, V. and Murphy, K. M.. (2016) Transcriptional Control of Dendritic Cell Development. Annu Rev Immunol, 34. pp. 93-119.

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The dendritic cells (DCs) of the immune system function in innate and adaptive responses by directing activity of various effector cells rather than serving as effectors themselves. DCs and closely related myeloid lineages share expression of many surface receptors, presenting a challenge in distinguishing their unique in vivo functions. Recent work has taken advantage of unique transcriptional programs to identify and manipulate murine DCs in vivo. This work has assigned several nonredundant in vivo functions to distinct DC lineages, consisting of plasmacytoid DCs and several subsets of classical DCs that promote different immune effector modules in response to pathogens. In parallel, a correspondence between human and murine DC subsets has emerged, underlying structural similarities for the DC lineages between these species. Recent work has begun to unravel the transcriptional circuitry that controls the development and diversification of DCs from common progenitors in the bone marrow.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Immune Regulation (Tussiwand)
UniBasel Contributors:Tussiwand, Roxane
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1545-3278 (Electronic) 0732-0582 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:25 May 2020 07:50
Deposited On:25 May 2020 07:50

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