Kretzer, N. M. and Theisen, D. J. and Tussiwand, R. and Briseno, C. G. and Grajales-Reyes, G. E. and Wu, X. and Durai, V. and Albring, J. and Bagadia, P. and Murphy, T. L. and Murphy, K. M.. (2016) RAB43 facilitates cross-presentation of cell-associated antigens by CD8alpha+ dendritic cells. J Exp Med, 213 (13). pp. 2871-2883.
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Official URL: https://edoc.unibas.ch/62506/
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Abstract
In this study, to examine cross-presentation by classical dendritic cells (DCs; cDCs), we evaluated the role of RAB43, a protein found to be selectively expressed by Batf3-dependent CD8alpha+ and CD103+ compared with other DC subsets and immune lineages. Using a specific monoclonal antibody, we localized RAB43 expression to the Golgi apparatus and LAMP1- cytoplasmic vesicles. Mice with germline or conditional deletion of Rab43 are viable and fertile and have normal development of cDCs but show a defect for in vivo and in vitro cross-presentation of cell-associated antigen. This defect is specific to cDCs, as Rab43-deficient monocyte-derived DCs showed no defect in cross-presentation of cell-associated antigen. These results suggest that RAB43 provides a specialized activity used in cross-presentation selectively by CD8alpha+ DCs but not other antigen-presenting cells.
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Immune Regulation (Tussiwand) |
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| UniBasel Contributors: | Tussiwand, Roxane |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| ISSN: | 1540-9538 (Electronic) 0022-1007 (Linking) |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 21 May 2020 14:01 |
| Deposited On: | 21 May 2020 14:01 |
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