Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny

Guilliams, Martin and Ginhoux, Florent and Jakubzick, Claudia and Naik, Shalin H. and Onai, Nobuyuki and Schraml, Barbara U. and Segura, Elodie and Tussiwand, Roxane and Yona, Simon. (2014) Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nature reviews. Immunology, 14 (8). pp. 571-578.

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Official URL: https://edoc.unibas.ch/62505/

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The mononuclear phagocyte system (MPS) has historically been categorized into monocytes, dendritic cells and macrophages on the basis of functional and phenotypical characteristics. However, considering that these characteristics are often overlapping, the distinction between and classification of these cell types has been challenging. In this Opinion article, we propose a unified nomenclature for the MPS. We suggest that these cells can be classified primarily by their ontogeny and secondarily by their location, function and phenotype. We believe that this system permits a more robust classification during both steady-state and inflammatory conditions, with the benefit of spanning different tissues and across species.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Immune Regulation (Tussiwand)
UniBasel Contributors:Tussiwand, Roxane
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Springer Nature
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:04 Aug 2020 12:48
Deposited On:04 Aug 2020 12:48

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