Transcriptional Hallmarks of Heterogeneous Neural Stem Cell Niches of the Subventricular Zone

Azim, Kasum and Hurtado-Chong, Anahì and Fischer, Bruno and Kumar, Nitin and Zweifel, Stefan and Taylor, Verdon and Raineteau, Olivier. (2015) Transcriptional Hallmarks of Heterogeneous Neural Stem Cell Niches of the Subventricular Zone. Stem Cells, 33 (7). pp. 2232-2242.

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Official URL: https://edoc.unibas.ch/62486/

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Throughout postnatal life in mammals, neural stem cells (NSCs) are located in the subventricular zone (SVZ) of the lateral ventricles. The greatest diversity of neuronal and glial lineages they generate occurs during early postnatal life in a region-specific manner. In order to probe heterogeneity of the postnatal SVZ, we microdissected its dorsal and lateral walls at different postnatal ages and isolated NSCs and their immediate progeny based on their expression of Hes5-EGFP/Prominin1 and Ascl1-EGFP, respectively. Whole genome comparative transcriptome analysis revealed transcriptional regulators as major hallmarks that sustain postnatal SVZ regionalization. Manipulation of single genes encoding for locally enriched transcription factors (loss-of-function or ectopic gain-of-function in vivo) influenced NSC specification indicating that the fate of regionalized postnatal SVZ-NSCs can be readily modified. These findings reveal the pronounced transcriptional heterogeneity of the postnatal SVZ and provide targets to recruit region-specific lineages in regenerative contexts. Stem Cells 2015;33:2232-2242.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Anatomy > Embryology and Stem Cell Biology (Taylor)
UniBasel Contributors:Taylor, Verdon
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1549-4918 (Electronic) 1066-5099 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Dec 2018 10:35
Deposited On:01 Dec 2018 10:35

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