Striatal astrocytes produce neuroblasts in an excitotoxic model of Huntington's disease

Nato, Giulia and Caramello, Alessia and Trova, Sara and Avataneo, Valeria and Rolando, Chiara and Taylor, Verdon and Buffo, Annalisa and Peretto, Paolo and Luzzati, Federico. (2015) Striatal astrocytes produce neuroblasts in an excitotoxic model of Huntington's disease. Development, 142 (5). pp. 840-845.

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Official URL: https://edoc.unibas.ch/62482/

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In the adult brain, subsets of astrocytic cells residing in well-defined neurogenic niches constitutively generate neurons throughout life. Brain lesions can stimulate neurogenesis in otherwise non-neurogenic regions, but whether local astrocytic cells generate neurons in these conditions is unresolved. Here, through genetic and viral lineage tracing in mice, we demonstrate that striatal astrocytes become neurogenic following an acute excitotoxic lesion. Similar to astrocytes of adult germinal niches, these activated parenchymal progenitors express nestin and generate neurons through the formation of transit amplifying progenitors. These results shed new light on the neurogenic potential of the adult brain parenchyma.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Anatomy > Embryology and Stem Cell Biology (Taylor)
UniBasel Contributors:Taylor, Verdon
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1477-9129 (Electronic) 0950-1991 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Dec 2018 10:30
Deposited On:01 Dec 2018 10:30

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