Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection

Lang, P. A. and Meryk, A. and Pandyra, A. A. and Brenner, D. and Brustle, A. and Xu, H. C. and Merches, K. and Lang, F. and Khairnar, V. and Sharma, P. and Funkner, P. and Recher, M. and Shaabani, N. and Duncan, G. S. and Duhan, V. and Homey, B. and Ohashi, P. S. and Haussinger, D. and Knolle, P. A. and Honke, N. and Mak, T. W. and Lang, K. S.. (2015) Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Cell Death & Differentiation subscription, 22 (1). pp. 164-173.

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During virus infection and autoimmune disease, inflammatory dendritic cells (iDCs) differentiate from blood monocytes and infiltrate infected tissue. Following acute infection with hepatotropic viruses, iDCs are essential for re-stimulating virus-specific CD8(+) T cells and therefore contribute to virus control. Here we used the lymphocytic choriomeningitis virus (LCMV) model system to identify novel signals, which influence the recruitment and activation of iDCs in the liver. We observed that intrinsic expression of Toso (Faim3, FcmuR) influenced the differentiation and activation of iDCs in vivo and DCs in vitro. Lack of iDCs in Toso-deficient (Toso(-/-)) mice reduced CD8(+) T-cell function in the liver and resulted in virus persistence. Furthermore, Toso(-/-) DCs failed to induce autoimmune diabetes in the rat insulin promoter-glycoprotein (RIP-GP) autoimmune diabetes model. In conclusion, we found that Toso has an essential role in the differentiation and maturation of iDCs, a process that is required for the control of persistence-prone virus infection.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Immunodeficiency (Recher)
UniBasel Contributors:Recher, Mike
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Nov 2018 18:16
Deposited On:19 Nov 2018 18:16

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