Anti-TNF and skin inflammation in IBD: a new paradox in gastroenterology?

Niess, Jan Hendrik and Danese, Silvio. (2014) Anti-TNF and skin inflammation in IBD: a new paradox in gastroenterology? Gut, 63 (4). pp. 533-535.

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Official URL: https://edoc.unibas.ch/62394/

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Meningothelial cells (MECs) are the cellular components of the meninges. As such, they provide important barrier function for the central nervous system (CNS) building the interface between neuronal tissue and the cerebrospinal fluid (CSF), and are also part of the immune response of the CNS. Human, immortalized MECs were analyzed by flow cytometry and confocal microscopy to study the uptake of apoptotic cells. Furthermore, cytokine and chemokine production by MECs was analyzed by cytokine array and ELISA. We found that MECs are highly active phagocytes able of ingesting and digesting large amounts of apoptotic cells. Furthermore, the uptake of apoptotic cells by MECs was immune suppressive via inhibiting the secretion of pro-inflammatory and chemoattractant cytokines and chemokines IL-6, IL-8, IL-16, MIF, and CXCL1, while increasing the secretion of anti-inflammatory IL-1 receptor antagonist by MECs. MECs respond with the secretion of anti-inflammatory cytokines and chemokines following the uptake of apoptotic cells potentially connecting these cells to processes important for the shut-down of immune responses in the brain.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Gastroenterology DBM (Niess)
UniBasel Contributors:Niess, Jan Hendrik
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:British Medical Association
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:03 Aug 2020 13:06
Deposited On:03 Aug 2020 13:04

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