Re-engineering development to instruct tissue regeneration

Tonnarelli, Beatrice and Centola, Matteo and Barbero, Andrea and Zeller, Rolf and Martin, Ivan. (2014) Re-engineering development to instruct tissue regeneration. In: Mechanisms of regeneration, 108. San Diego, pp. 319-338.

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Official URL: https://edoc.unibas.ch/62354/

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With few exceptions, tissue regeneration strategies based on the conventional combination of cells, scaffolding materials, and soluble factors (tissue engineering) have introduced a rather limited clinical impact. While it is being recognized that the non-convincing benefits of engineered grafts require more fundamental knowledge on mechanisms of action and potency factors, the attempt to mimic and recapitulate developmental events has inspired an evolution of the paradigm. In the context of skeletal regeneration, a "developmental engineering" approach has been advocated to generate intermediate grafts (i.e., hypertrophic cartilage templates) which, as suggested by limb developmental biology, are capable of autonomous spatial and temporal evolution into fully functional bone organs. However, limited consideration has been given to the fact that the recipient site within adult organisms may not be compatible with well-established developmental processes. This can be due to the possibly restricted function of resident progenitors, to the critical mechanical and physical boundary conditions of mature organs, or to the strong role of inflammatory signals and immune cells at repair sites. We thus propose that predictable, orderly, and durable tissue regeneration should be based on a "developmental RE-engineering" paradigm, with the challenge to instruct the execution of developmental programs in the context of an adult system.
Faculties and Departments:03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Querschnittsbereich Forschung > Tissue Engineering (Martin)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Querschnittsbereich Forschung > Tissue Engineering (Martin)
03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Tissue Engineering (Martin)
03 Faculty of Medicine > Departement Biomedizin > Division of Anatomy > Developmental Genetics (Zeller/Zuniga)
UniBasel Contributors:Martin, Ivan and Zeller, Rolf
Item Type:Book Section, refereed
Book Section Subtype:Further Contribution in a Book
Publisher:Academic Press
Series Name:Current Topics in Developmental Biology
Note:Publication type according to Uni Basel Research Database: Book item
Identification Number:
Last Modified:17 Apr 2019 11:46
Deposited On:17 Apr 2019 11:46

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