Endothelial-to-hematopoietic transition: Notch-ing vessels into blood

Kanz, Dirk and Konantz, Martina and Alghisi, Elisa and North, Trista E. and Lengerke, Claudia. (2016) Endothelial-to-hematopoietic transition: Notch-ing vessels into blood. Annals of the New York Academy of Sciences, 1370 (1). pp. 97-108.

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Official URL: https://edoc.unibas.ch/62307/

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During development, hematopoietic stem cells (HSCs) are formed in a temporally and spatially restricted manner, arising from specialized endothelial cells (ECs) in the ventral wall of the dorsal aorta within the evolutionary conserved aorta-gonad-mesonephros region. Our understanding of the processes regulating the birth of HSCs from ECs has been recently advanced by comprehensive molecular analyses of developing murine hematopoietic cell populations complemented by studies in the zebrafish model, with the latter offering unique advantages for genetic studies and direct in vivo visualization of HSC emergence. Here, we provide a concise review of the current knowledge and recent advances regarding the cellular origin and molecular regulation of HSC development, with particular focus on the process of endothelial-to-hematopoietic transition and its primary regulator, the Notch signaling pathway.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Stem Cells and Hematopoiesis (Lengerke)
03 Faculty of Medicine > Departement Biomedizin
UniBasel Contributors:Lengerke, Claudia and Konantz, Martina
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Jun 2021 14:25
Deposited On:26 May 2018 17:53

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