Extreme exercise enhances chromogranin A levels correlating with stress levels but not with cardiac burden

Nickel, T. and Vogeser, M. and Emslander, I. and David, R. and Heilmeier, B. and op den Winkel, M. and Schmidt-Trucksäss, A. and Wilbert-Lampen, U. and Hanssen, Henner and Halle, M.. (2012) Extreme exercise enhances chromogranin A levels correlating with stress levels but not with cardiac burden. Atherosclerosis, 220 (1). pp. 219-222.

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OBJECTIVE: Stress and heart failure are associated with increased systemic levels of chromogranin A (CGA). Here we analyzed the effects of marathon running on systemic CGA levels and the association with cardiac burden and stress.
METHODS: We recruited 47 lean and obese runners for a 10week training program aiming at running a marathon. Heart rates, individual fitness and marathon finishing times were monitored. CGA, proBNP and troponin T levels were analyzed by ELISA.
RESULTS: We found a significant increase of CGA (+51%; p<0.01) in lean runners after marathon. The obese group showed the highest troponin T (0.22ng/ml; p<0.01) and proBNP (176.6ng/ml; p<0.01) levels. There were no correlations between proBNP, troponin T and CGA. An inverse correlation (r=-0.45; p<0.01) was found between CGA and finishing times.
CONCLUSION: Marathon running is associated with increased CGA levels. However, this does not seem to reflect cardiac burden but rather marathon induced stress.
Faculties and Departments:03 Faculty of Medicine > Departement Sport, Bewegung und Gesundheit > Bereich Sport- und Bewegungsmedizin > Präventive Sportmedizin (Hanssen)
UniBasel Contributors:Hanssen, Henner
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 Aug 2018 09:44
Deposited On:22 Aug 2018 16:54

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