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Obsessive-compulsive disorder and the risk of subsequent mental disorders: A community study of adolescents and young adults

Hofer, Patrizia D. and Wahl, Karina and Meyer, Andrea H. and Miché, Marcel and Beesdo-Baum, Katja and Wong, Shiu F. and Grisham, Jessica R. and Wittchen, Hans-Ulrich and Lieb, Roselind. (2018) Obsessive-compulsive disorder and the risk of subsequent mental disorders: A community study of adolescents and young adults. Depression and Anxiety, 35 (4). pp. 339-345.

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Official URL: https://edoc.unibas.ch/62239/

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Abstract

Comorbidity of obsessive-compulsive disorder (OCD) with other mental disorders has been demonstrated repeatedly. Few longitudinal studies, however, have evaluated the temporal association of prior OCD and subsequent mental disorders across the age period of highest risk for first onset of mental disorders. We examined associations between prior OCD and a broad range of subsequent mental disorders and simulated proportions of new onsets of mental disorders that could potentially be attributed to prior OCD, assuming a causal relationship.; Data from 3,021 14- to 24-year-old community subjects were prospectively collected for up to 10 years. DSM-IV OCD and other DSM-IV mental disorders were assessed with the Munich-Composite International Diagnostic Interview. We used adjusted time-dependent proportional hazard models to estimate the temporal associations of prior OCD with subsequent mental disorders.; Prior OCD was associated with an increased risk of bipolar disorders (BIP; [hazard ratio, HR = 6.9, 95% confidence interval, CI, (2.8,17.3)], bulimia nervosa [HR = 6.8 (1.3,36.6)], dysthymia [HR = 4.4 (2.1,9.0)], generalized anxiety disorder (GAD; [HR = 3.4 (1.1,10.9)], and social phobia [HR = 2.9 (1.1,7.7)]). Of these outcome disorders, between 65 and 85% could be attributed to OCD in the exposed group, whereas between 1.5 and 7.7% could be attributed to OCD in the total sample.; This study provides strong evidence that prior OCD is associated with an increased risk of subsequent onset of BIP, bulimia nervosa, dysthymia, GAD, and social phobia among adolescents and young adults. Future studies should evaluate if early treatment of OCD can prevent the onset of these subsequent mental disorders.
Faculties and Departments:07 Faculty of Psychology
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Epidemiologie (Lieb)
UniBasel Contributors:Meyer, Andrea Hans and Wahl, Karina and Miché, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:1091-4269
e-ISSN:1520-6394
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:13 Mar 2019 11:01
Deposited On:29 May 2018 13:59

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