Ibanescu, S. A. and Nowakowska, J. and Khanna, N. and Landmann, R. and Klok, H. A.. (2016) Effects of Grafting Density and Film Thickness on the Adhesion of Staphylococcus epidermidis to Poly(2-hydroxy ethyl methacrylate) and Poly(poly(ethylene glycol)methacrylate) Brushes. Macromol Biosci, 16 (5). pp. 676-685.
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Official URL: https://edoc.unibas.ch/62171/
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Abstract
Thin polymer films that prevent the adhesion of bacteria are of interest as coatings for the development of infection-resistant biomaterials. This study investigates the influence of grafting density and film thickness on the adhesion of Staphylococcus epidermidis to poly(poly(ethylene glycol)methacrylate) (PPEGMA) and poly(2-hydroxyethyl methacrylate) (PHEMA) brushes prepared via surface-initiated atom transfer radical polymerization (SI-ATRP). These brushes are compared with poly(ethylene glycol) (PEG) brushes, which are obtained by grafting PEG onto an epoxide-modified substrate. Except for very low grafting densities (rho = 1%), crystal violet staining experiments show that the PHEMA and PPEGMA brushes are equally effective as the PEG-modified surfaces in preventing S. epidermis adhesion and do not reveal any significant variations as a function of film thickness or grafting density. These results indicate that brushes generated by SI-ATRP are an attractive alternative to grafted-onto PEG films for the preparation of surface coatings that resist bacterial adhesion.
Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Infection Biology (Khanna) |
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UniBasel Contributors: | Khanna, Nina |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
ISSN: | 1616-5195 (Electronic) 1616-5187 (Linking) |
Note: | Publication type according to Uni Basel Research Database: Journal article |
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Last Modified: | 31 May 2020 17:19 |
Deposited On: | 31 May 2020 17:19 |
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