Targeting microRNAs for immunomodulation

Jeker, L. T. and Marone, R.. (2015) Targeting microRNAs for immunomodulation. Current Opinion in Pharmacology, 23. pp. 25-31.

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Official URL: https://edoc.unibas.ch/62146/

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microRNAs (miRNA) are small regulatory RNAs exerting pleiotropic functions in virtually any immune cell-type. Dozens of miRNAs with a known function in the immune system constitute interesting drug targets for immunomodulation. Chemical modifications of nucleic acid-based miRNA mimics and inhibitors largely solved instability issues but delivery to immune cells remains a major challenge. However, recent success targeting the acidic tumor microenvironment is very promising for inflammatory diseases. Moreover, small molecules are being explored as an interesting alternative. Although RNA is often considered 'undruggable' by small molecules recent progress modulating miRNA function through small molecules is encouraging. Computational approaches even allow predictions about specific small molecule/RNA interactions. Finally, recent clinical success demonstrates that drugs targeting RNAs work in humans.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Molecular Immune Regulation (Jeker)
UniBasel Contributors:Jeker, Lukas T.
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Elsevier Science
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:13 Nov 2018 19:18
Deposited On:13 Nov 2018 19:18

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