Small RNA regulators of T cell-mediated autoimmunity

Jeker, Lukas T. and Bluestone, Jeffrey A.. (2010) Small RNA regulators of T cell-mediated autoimmunity. Journal of Clinical Immunology, 30 (3). pp. 347-357.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/61967/

Downloads: Statistics Overview


MicroRNAs (miRNAs) are short singlestranded RNA molecules that regulate gene expression post-transcriptionally. Several hundred miRNAs exist in the mammalian genome and regulate developmental processes, cell cycle, and survival.; In this review,we highlight generalmodes of miRNA function and relate them to how such regulation can be beneficial for immune homeostasis and the prevention of autoimmune diseases.We highlight examples of experimentally verified miRNA function and their target genes in the immune system and place them in context of concepts relevant to an understanding of autoimmune pathogenesis. Where available, we refer to clinical correlations. Finally, we speculate how emerging knowledge about miRNA function in the immune system might be used diagnostically and therapeutically.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Molecular Immune Regulation (Jeker)
UniBasel Contributors:Jeker, Lukas T.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:15 Dec 2020 11:57
Deposited On:15 Dec 2020 11:57

Repository Staff Only: item control page