de Kouchkovsky, Dimitri and Esensten, Jonathan H. and Rosenthal, Wendy L. and Morar, Malika M. and Bluestone, Jeffrey A. and Jeker, Lukas T.. (2013) microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis. Journal of Immunology, 191 (4). pp. 1594-1605.
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Official URL: https://edoc.unibas.ch/61958/
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Abstract
microRNAs (miRNA) are essential for regulatory T cell (Treg) function but little is known about the functional relevance of individual miRNA loci. We identified the miR-17-92 cluster as CD28 costimulation dependent, suggesting that it may be key for Treg development and function. Although overall immune homeostasis was maintained in mice with miR-17-92-deficient Tregs, expression of the miR-17-92 miRNA cluster was critical for Treg accumulation and function during an acute organ-specific autoimmune disease in vivo. Treg-specific loss of miR-17-92 expression resulted in exacerbated experimental autoimmune encephalitis and failure to establish clinical remission. Using peptide-MHC tetramers, we demonstrate that the miR-17-92 cluster was specifically required for the accumulation of activated Ag-specific Treg and for differentiation into IL-10-producing effector Treg.
Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Molecular Immune Regulation (Jeker) |
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UniBasel Contributors: | Jeker, Lukas T. |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | American Association of Immunologists |
ISSN: | 0022-1767 |
e-ISSN: | 1550-6606 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
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Identification Number: |
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Last Modified: | 16 Dec 2020 07:53 |
Deposited On: | 16 Dec 2020 07:53 |
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