High frequency of CD8 positive lymphocyte infiltration correlates with lack of lymph node involvement in early rectal cancer

Däster, Silvio and Eppenberger-Castori, Serenella and Hirt, Christian and Zlobec, Inti and Delko, Tarik and Nebiker, Christian A. and Soysal, Savas D. and Amicarella, Francesca and Iezzi, Giandomenica and Sconocchia, Giuseppe and Heberer, Michael and Lugli, Alessandro and Spagnoli, Giulio C. and Kettelhack, Christoph and Terracciano, Luigi and Oertli, Daniel and von Holzen, Urs and Tornillo, Luigi and Droeser, Raoul A.. (2014) High frequency of CD8 positive lymphocyte infiltration correlates with lack of lymph node involvement in early rectal cancer. Disease Markers, 2014. p. 792183.

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Official URL: https://edoc.unibas.ch/61941/

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AIMS: A trend towards local excision of early rectal cancers has prompted us to investigate if immunoprofiling might help in predicting lymph node involvement in this subgroup. METHODS: A tissue microarray of 126 biopsies of early rectal cancer (T1 and T2) was stained for several immunomarkers of the innate and the adaptive immune response. Patients' survival and nodal status were analyzed and correlated with infiltration of the different immune cells. RESULTS: Of all tested markers, only CD8 (P = 0.005) and TIA-1 (P = 0.05) were significantly more frequently detectable in early rectal cancer biopsies of node negative as compared to node positive patients. Although these two immunomarkers did not display prognostic effect "per se," CD8+ and, marginally, TIA-1 T cell infiltration could predict nodal involvement in univariate logistic regression analysis (OR 0.994; 95% CI 0.992-0.996; P = 0.009 and OR 0.988; 95% CI 0.984-0.994; P = 0.05, resp.). An algorithm significantly predicting the nodal status in early rectal cancer based on CD8 together with vascular invasion and tumor border configuration could be calculated (P > 0.00001). CONCLUSION: Our data indicate that in early rectal cancers absence of CD8+ T-cell infiltration helps in predicting patients' nodal involvement.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Cancer Immunotherapy (Iezzi)
UniBasel Contributors:Iezzi, Giandomenica
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Jul 2020 14:45
Deposited On:27 Jul 2020 14:45

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