BK Polyomavirus Infection and Renourinary Tumorigenesis

Papadimitriou, J. C. and Randhawa, P. and Rinaldo, C. H. and Drachenberg, C. B. and Alexiev, B. and Hirsch, H. H.. (2016) BK Polyomavirus Infection and Renourinary Tumorigenesis. Am J Transplant, 16 (2). pp. 398-406.

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Official URL: https://edoc.unibas.ch/61881/

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BK polyomavirus (BKPyV) infection represents a major problem in transplantation, particularly for renal recipients developing polyomavirus-associated nephropathy (PyVAN). The possibility that BKPyV may also be oncogenic is not routinely considered. Twenty high-grade renourinary tumors expressing polyomavirus large T antigen in the entirety of the neoplasm in 19 cases, including the metastases in six, have been reported in transplant recipients with a history of PyVAN or evidence of BKPyV infection. Morphological and phenotypical features consistent with inactivation of the tumor suppressors pRB and p53 were found in the bladder tumors, suggesting a carcinogenesis mechanism involving the BKPyV large tumor oncoprotein/antigen. The pathogenesis of these tumors is unclear, but given the generally long interval between transplantation and tumor development, the risk for neoplasms after BKPyV infections may well be multifactorial. Other elements potentially implicated include exposure to additional exogenous carcinogens, further viral mutations, and cell genomic instability secondary to viral integration, as occurs with the Merkel cell PyV-associated carcinoma. The still scarce but increasingly reported association between longstanding PyVAN and renourinary neoplasms requires a concerted effort from the transplant community to better understand, diagnose, and treat the putative association between the BKPyV and these neoplasms.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Transplantation Virology (Hirsch)
UniBasel Contributors:Hirsch, Hans H.
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
ISSN:1600-6143 (Electronic) 1600-6135 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:31 May 2020 21:21
Deposited On:31 May 2020 21:21

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