Reliable in vitro studies require appropriate ovarian cancer cell lines

Jacob, Francis and Nixdorf, Shery and Hacker, Neville F. and Heinzelmann-Schwarz, Viola A.. (2014) Reliable in vitro studies require appropriate ovarian cancer cell lines. Journal of ovarian research, 7. p. 60.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/61860/

Downloads: Statistics Overview


Ovarian cancer is the fifth most common cause of cancer death in women and the leading cause of death from gynaecological malignancies. Of the 75% women diagnosed with locally advanced or disseminated disease, only 30% will survive five years following treatment. This poor prognosis is due to the following reasons: limited understanding of the tumor origin, unclear initiating events and early developmental stages of ovarian cancer, lack of reliable ovarian cancer-specific biomarkers, and drug resistance in advanced cases. In the past, in vitro studies using cell line models have been an invaluable tool for basic, discovery-driven cancer research. However, numerous issues including misidentification and cross-contamination of cell lines have hindered research efforts. In this study we examined all ovarian cancer cell lines available from cell banks. Hereby, we identified inconsistencies in the reporting, difficulties in the identification of cell origin or clinical data of the donor patients, restricted ethnic and histological type representation, and a lack of tubal and peritoneal cancer cell lines. We recommend that all cell lines should be distributed via official cell banks only with strict guidelines regarding the minimal available information required to improve the quality of ovarian cancer research in future.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Gynecological Research (Heinzelmann)
UniBasel Contributors:Heinzelmann, Viola
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:BioMed Central Ltd
Note:Publication type according to Uni Basel Research Database: Journal item
Related URLs:
Identification Number:
Last Modified:23 Jul 2020 15:35
Deposited On:23 Jul 2020 15:35

Repository Staff Only: item control page