Clinical significance of the CCR5delta32 allele in hepatitis C

Morard, Isabelle and Clement, Sophie and Calmy, Alexandra and Mangia, Alessandra and Cerny, Andrea and de Gottardi, Andrea and Gorgievski, Meri and Heim, Markus and Malinverni, Raffaele and Moradpour, Darius and Müllhaupt, Beat and Semela, David and Pascarella, Stéphanie and Bochud, Pierre-Yves and Negro, Franco and Swiss Hepatitis C. Cohort Study Group, . (2014) Clinical significance of the CCR5delta32 allele in hepatitis C. PLoS ONE, 9 (9). e106424.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/61798/

Downloads: Statistics Overview


The CCR5 receptor, expressed on Th1 cells, may influence clinical outcomes of HCV infection. We explored a possible link between a CCR5 32-base deletion (CCR5delta32), resulting in the expression of a non-functioning receptor, and clinical outcomes of HCV infection. CCR5 and HCV-related phenotypes were analysed in 1,290 chronically infected patients and 160 patients with spontaneous clearance. Carriage of the CCR5delta32 allele was observed in 11% of spontaneous clearers compared to 17% of chronically infected patients (OR = 0.59, 95% CI interval 0.35-0.99, P = 0.047). Carriage of this allele also tended to be observed more frequently among patients with liver inflammation (19%) compared to those without inflammation (15%, OR = 1.38, 95% CI interval 0.99-1.95, P = 0.06). The CCR5delta32 was not associated with sustained virological response (P = 0.6), fibrosis stage (P = 0.8), or fibrosis progression rate (P = 0.4). The CCR5delta32 allele appears to be associated with a decreased rate of spontaneous HCV eradication, but not with hepatitis progression or response to antiviral therapy.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Hepatology Laboratory (Heim)
UniBasel Contributors:Heim, Markus H.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Public Library of Science
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:16 Dec 2020 07:45
Deposited On:16 Dec 2020 07:45

Repository Staff Only: item control page