edoc

Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes

Terczyńska-Dyla, Ewa and Bibert, Stephanie and Duong, Francois H. T. and Krol, Ilona and Jørgensen, Sanne and Collinet, Emilie and Kutalik, Zoltán and Aubert, Vincent and Cerny, Andreas and Kaiser, Laurent and Malinverni, Raffaele and Mangia, Alessandra and Moradpour, Darius and Müllhaupt, Beat and Negro, Francesco and Santoro, Rosanna and Semela, David and Semmo, Nasser and Swiss Hepatitis C. Cohort Study Group, and Heim, Markus H. and Bochud, Pierre-Yves and Hartmann, Rune. (2014) Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes. Nature Communications, 5. p. 5699.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/61757/

Downloads: Statistics Overview

Abstract

Hepatitis C virus (HCV) infections are the major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma worldwide. Both spontaneous and treatment-induced clearance of HCV depend on genetic variation within the interferon-lambda locus, but until now no clear causal relationship has been established. Here we demonstrate that an amino-acid substitution in the IFNλ4 protein changing a proline at position 70 to a serine (P70S) substantially alters its antiviral activity. Patients harbouring the impaired IFNλ4-S70 variant display lower interferon-stimulated gene (ISG) expression levels, better treatment response rates and better spontaneous clearance rates, compared with patients coding for the fully active IFNλ4-P70 variant. Altogether, these data provide evidence supporting a role for the active IFNλ4 protein as the driver of high hepatic ISG expression as well as the cause of poor HCV clearance.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Hepatologie > Hepatologie (Heim)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Hepatologie > Hepatologie (Heim)
03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Hepatology Laboratory (Heim)
UniBasel Contributors:Heim, Markus H.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
e-ISSN:2041-1723
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:03 Aug 2020 11:48
Deposited On:03 Aug 2020 11:48

Repository Staff Only: item control page