Interleukin-6 contributes to early fasting-induced free fatty acid mobilization in mice

Wueest, Stephan and Item, Flurin and Boyle, Christina N. and Jirkof, Paulin and Cesarovic, NNikola and Ellingsgaard, Helga and Böni-Schnetzler, Marianne and Timper, Katharina and Arras, Margarete and Donath, Marc Y. and Lutz, Thomas A. and Schoenle, Eugen J. and Konrad, Daniel. (2014) Interleukin-6 contributes to early fasting-induced free fatty acid mobilization in mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 306 (11). R861-R867.

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Contracting muscle releases interleukin-6 (IL-6) enabling the metabolic switch from carbohydrate to fat utilization. Similarly, metabolism is switched during transition from fed to fasting state. Herein, we examined a putative role for IL-6 in the metabolic adaptation to normal fasting. In lean C57BL/6J mice, 6 h of food withdrawal increased gene transcription levels of IL-6 in skeletal muscle but not in white adipose tissue. Concomitantly, circulating IL-6 and free fatty acid (FFA) levels were significantly increased, whereas respiratory quotient (RQ) was reduced in 6-h fasted mice. In white adipose tissue, phosphorylation of hormone-sensitive lipase (HSL) was increased on fasting, indicating increased lipolysis. Intriguingly, fasting-induced increase in circulating IL-6 levels and parallel rise in FFA concentration were absent in obese and glucose-intolerant mice. A causative role for IL-6 in the physiological adaptation to fasting was further supported by the fact that fasting-induced increase in circulating FFA levels was significantly blunted in lean IL-6 knockout (KO) and lean C57BL/6J mice treated with neutralizing IL-6 antibody. Consistently, phosphorylation of HSL was significantly reduced in adipose tissue of IL-6-depleted mice. Hence, our findings suggest a novel role for IL-6 in energy supply during early fasting.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Diabetes Research (Donath)
UniBasel Contributors:Donath, Marc
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Physiological Society
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 Jul 2020 13:38
Deposited On:21 Jul 2020 15:26

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