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Muscle-Derived IL-6 Is Not Regulated by IL-1 during Exercise. A Double Blind, Placebo-Controlled, Randomized Crossover Study

Nordmann, Thierry M. and Seelig, Eleonara and Timper, Katharina and Cordes, Mareike and Coslovsky, Michael and Hanssen, Henner and Schmidt-Trucksäss, Arno and Donath, Marc Y.. (2015) Muscle-Derived IL-6 Is Not Regulated by IL-1 during Exercise. A Double Blind, Placebo-Controlled, Randomized Crossover Study. PLoS ONE, 10 (10). e0139662.

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Official URL: https://edoc.unibas.ch/61697/

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Abstract

Exercise increases muscle derived Interleukin-6 (IL-6) leading to insulin secretion via glucagon-like peptide-1. IL-1 antagonism improves glycemia and decreases systemic inflammation including IL-6 in patients with type 2 diabetes. However, it is not known whether physiological, exercise-induced muscle-derived IL-6 is also regulated by the IL-1 system. Therefore we conducted a double blind, crossover study in 17 healthy male subjects randomized to receive either the IL-1 receptor antagonist IL-1Ra (anakinra) or placebo prior to an acute treadmill exercise. Muscle activity led to a 2-3 fold increase in serum IL-6 concentrations but anakinra had no effect on this exercise-induced IL-6. Furthermore, the IL-1 responsive inflammatory markers CRP, cortisol and MCP-1 remained largely unaffected by exercise and anakinra. We conclude that the beneficial effect of muscle-induced IL-6 is not meaningfully affected by IL-1 antagonism.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Diabetes Research (Donath)
UniBasel Contributors:Donath, Marc
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Public Library of Science
e-ISSN:1932-6203
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Nov 2018 08:54
Deposited On:22 Aug 2018 15:48

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