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Unraveling natalizumab effects on deregulated miR-17 expression in CD4+ T cells of patients with relapsing-remitting multiple sclerosis

Meira, Meira and Sievers, Claudia and Hoffmann, Francine and Rasenack, Maria and Kuhle, Jens and Derfuss, Tobias and Kappos, Ludwig and Lindberg, Raija L. P.. (2014) Unraveling natalizumab effects on deregulated miR-17 expression in CD4+ T cells of patients with relapsing-remitting multiple sclerosis. Journal of Immunology Research, 2014. p. 897249.

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Official URL: https://edoc.unibas.ch/61687/

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Abstract

MicroRNAs (miRNAs) are a family of noncoding RNAs that play critical roles in the posttranscriptional regulation of gene expression. Accumulating evidence supports their involvement in the pathogenesis of multiple sclerosis (MS). Here, we compare miR-17 expressions in CD4+ T cells from relapsing-remitting (RR) MS patients treated with natalizumab versus untreated patients. miR-17 was downregulated under natalizumab treatment and upregulated during relapse, therefore supporting a possible role of miR-17 in MS immunopathogenesis. Downregulation of miR-17 was associated with upregulation of PTEN, BIM, E2F1, and p21 target genes. In vitro miR-17 inhibition was associated with upregulation of the same targets and resulted in impaired CD4+ T cell activation and proliferation. We further describe deregulated TGFBR2 expression in untreated patients versus healthy volunteers (HVs) and confirm in vitro the link between miR-17 and TGFBR2 expressions. These findings support an effect of natalizumab on expression of specific miRNA and subsequent expression of genes involved in proliferation and control of the cell cycle.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Clinical Neuroimmunology (Derfuss/Lindberg)
UniBasel Contributors:Derfuss, Tobias Johannes and Lindberg Gasser, Raija L.P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Hindawi
ISSN:2314-8861
e-ISSN:2314-7156
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:21 Jul 2020 14:36
Deposited On:21 Jul 2020 14:36

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