Phosphoantigen Presentation to TCR gammadelta Cells, a Conundrum Getting Less Gray Zones

De Libero, Gennaro and Lau, Sze-Yi and Mori, Lucia. (2015) Phosphoantigen Presentation to TCR gammadelta Cells, a Conundrum Getting Less Gray Zones. Frontiers in Immunology, 5. p. 679.

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The mechanistic requirements of antigen recognition by T cells expressing a gammadelta TCR has revealed important differences with those of alphabeta TCR cells and, despite impressive new data generated in the very recent years, they remain poorly understood. Based on the structure of the TCR chains and the tissue distribution, gammadelta cells are represented in a variety of populations. The major subset of human peripheral blood gammadelta cells express Vgamma9Vdelta2 TCR heterodimers and are all stimulated by phosphorylated metabolites (commonly called phosphoantigens). Phosphoantigens are molecules with a very small mass and only stimulate Vgamma9Vdelta2 cells in the presence of antigen-presenting cells, suggesting a strict requirement for dedicated antigen-presenting molecules. Recent studies have identified butyrophilin (BTN) 3A1 as the molecule necessary to stimulate Vgamma9Vdelta2 cells. BTN3A1 extracellular, transmembrane, and cytoplasmic domains have different functions, including cognate interaction with the Vgamma9Vdelta2 TCR, binding of the phosphoantigens, and interaction with cytoplasmic proteins. This review mainly discusses the known molecular mechanisms of BTN3A1-mediated antigen presentation to gammadelta cells and proposes a model of phosphoantigen presentation, which integrates past and recent studies.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Experimental Immunology (De Libero)
UniBasel Contributors:De Libero, Gennaro
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Frontiers Media
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:03 Aug 2020 08:19
Deposited On:03 Aug 2020 08:19

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