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Emerging technologies for monitoring drug-resistant tuberculosis at the point-of-care

Mani, Vigneshwaran and Wang, Shuqi and Inci, Fatih and De Libero, Gennaro and Singhal, Amit and Demirci, Utkan. (2014) Emerging technologies for monitoring drug-resistant tuberculosis at the point-of-care. Advanced Drug Delivery Reviews, 78. pp. 105-117.

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Official URL: https://edoc.unibas.ch/61653/

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Abstract

Infectious diseases are the leading cause of death worldwide. Among them, tuberculosis (TB) remains a major threat to public health, exacerbated by the emergence of multiple drug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis (Mtb). MDR-Mtb strains are resistant to first-line anti-TB drugs such as isoniazid and rifampicin; whereas XDR-Mtb strains are resistant to additional drugs including at least to any fluoroquinolone and at least one of the second-line anti-TB injectable drugs such as kanamycin, capreomycin, or amikacin. Clinically, these strains have significantly impacted the management of TB in high-incidence developing countries, where systemic surveillance of TB drug resistance is lacking. For effective management of TB on-site, early detection of drug resistance is critical to initiate treatment, to reduce mortality, and to thwart drug-resistant TB transmission. In this review, we discuss the diagnostic challenges to detect drug-resistant TB at the point-of-care (POC). Moreover, we present the latest advances in nano/microscale technologies that can potentially detect TB drug resistance to improve on-site patient care.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Experimental Immunology (De Libero)
UniBasel Contributors:De Libero, Gennaro
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Elsevier
ISSN:0169-409X
e-ISSN:1872-8294
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:20 Jul 2020 15:55
Deposited On:20 Jul 2020 15:55

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