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Targeting leukemia by CD1c-restricted T cells specific for a novel lipid antigen

Lepore, Marco and de Lalla, Claudia and Mori, Lucia and Dellabona, Paolo and De Libero, Gennaro and Casorati, Giulia. (2015) Targeting leukemia by CD1c-restricted T cells specific for a novel lipid antigen. Oncoimmunology, 4 (3). e970463.

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Official URL: https://edoc.unibas.ch/61650/

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Abstract

A subset of CD1c-restricted T lymphocytes exhibits strong reactivity against leukemia cells. These T cells recognize methyl-lysophosphatidic acid (mLPA), a novel lipid antigen produced by acute leukemia cells. Considering that CD1c-restricted T cells display efficacious anti-leukemia activities in a mouse model, this lipid antigen thus represents a novel target in the immunotherapy of hematological malignancies.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Experimental Immunology (De Libero)
UniBasel Contributors:De Libero, Gennaro
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:2162-4011 (Print) 2162-4011 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Oct 2018 07:50
Deposited On:27 Oct 2018 07:50

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