Lepore, Marco and de Lalla, Claudia and Mori, Lucia and Dellabona, Paolo and De Libero, Gennaro and Casorati, Giulia. (2015) Targeting leukemia by CD1c-restricted T cells specific for a novel lipid antigen. Oncoimmunology, 4 (3). e970463.
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Official URL: https://edoc.unibas.ch/61650/
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Abstract
A subset of CD1c-restricted T lymphocytes exhibits strong reactivity against leukemia cells. These T cells recognize methyl-lysophosphatidic acid (mLPA), a novel lipid antigen produced by acute leukemia cells. Considering that CD1c-restricted T cells display efficacious anti-leukemia activities in a mouse model, this lipid antigen thus represents a novel target in the immunotherapy of hematological malignancies.
Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Experimental Immunology (De Libero) |
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UniBasel Contributors: | De Libero, Gennaro |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
ISSN: | 2162-4011 (Print) 2162-4011 (Linking) |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Related URLs: | |
Identification Number: |
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Last Modified: | 27 Oct 2018 07:50 |
Deposited On: | 27 Oct 2018 07:50 |
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