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Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Paternoster, Lavinia and Standl, Marie and Waage, Johannes and Baurecht, Hansjörg and Hotze, Melanie and Strachan, David P. and Curtin, John A. and Bønnelykke, Klaus and Tian, Chao and Takahashi, Atsushi and Esparza-Gordillo, Jorge and Alves, Alexessander Couto and Thyssen, Jacob P. and den Dekker, Herman T. and Ferreira, Manuel A. and Altmaier, Elisabeth and Sleiman, Patrick M. and Xiao, Feng Li and Gonzalez, Juan R. and Marenholz, Ingo and Kalb, Birgit and Pino-Yanes, Maria and Xu, Cheng Jian and Carstensen, Lisbeth and Groen-Blokhuis, Maria M. and Venturini, Cristina and Pennell, Craig E. and Barton, Sheila J. and Levin, Arbet M. and Curjuric, Ivan and Bustamante, Mariona and Kreiner-Møller, Eskil and Lockett, Gabrielle A. and Bacelis, Jonas and Bunyavanich, Supinda and Myers, Rachel A. and Matanovic, Anja and Kumar, Ashish and Tung, Joyce Y and Hirota, Tomomitsu and Kubo, Michiaki and McArdle, Wendy L. and Henderson, A. John and Kemp, John P. and Zheng, Jie and Smith, George Davey and Rüschendorf, Franz and Bauerfeind, Anja and Lee-Kirsch, Min Ae and Arnold, Andreas and Homuth, Georg and Schmidt, Carsten O. and Mangold, Elisabeth and Cichon, Sven and Keil, Thomas and Rodríguez, Elke and Peters, Annette and Franke, Andre and Lieb, Wolfgang and Novak, Natalija and Fölster-Holst, Regina and Horikoshi, Momoko and Pekkanen, Juha and Sebert, Sylvain and Husemoen, Lise L. and Grarup, Niels and de Jongste, Johan C. and Rivadeneira, Fernando and Hofman, Albert and Jaddoe, Vincent W. V. and Pasmans, Suzanne G. M. A. and Elbert, Niels J. and Uitterlinden, André G. and Marks, Guy B. and Thompson, Philip J. and Matheson, Melanie C. and Robertson, Colin F. and Australian Asthma Genetics, Consortium (AAGC) and Ried, Janina S. and Li, Jin and Zuo, Xian Bo and Zheng, Xiao Dong and Yin, Xian Yong Yin and Sun, Liang Dan and McAleer, Maeve A. and O'Regan, Grainne M. and Fahy, Caoimhe M. R. and Campbell, Linda E. and Macek, Milan and Kurek, Michael and Hu, Donglei and Eng, Celeste and Postma, Dirkje S. and Feenstra, Bjarke and Geller, Frank and Hottenga, Jouke Jan and Middeldorp, Christel M. and Hysi, Pirro and Bataille, Veronique and Spector, Tim and Tiesler, Carla M. T. and Thiering, Elisabeth and Pahukasahasram, Badri and Yang, James J. and Imboden, Madea and Huntsman, Scott and Vilor-Tejedor, Natàlia and Relton, Caroline L. and Myhre, Ronny and Nystad, Wenche and Custovic, Adnan and Weiss, Scott T. and Meyers, Deborah A. and Soderhall, Cilla and Melén, Erik and Ober, Carole and Raby, Benjamin A. and Simpson, Angela and Jacobsson, Bo and Holloway, John W. and Bisgaard, Hans and Sunyer, Jordi and Probst-Hensch, Nicole M. and Williams, L. Keoki and Godfrey, Keith M. and Wang, Carol A. and Boomsma, Dorret I. and Melbye, Mads and Koppelman, Gerard H. and Jarvis, Deborah and McLean, W. H. Irwin and Irvine, Alan D. and Zhang, Xue Jun and Hakonarson, Hakon and Gieger, Christian and Burchard, Esteban G. and Martin, Nicholas G. and Duijts, Liesbeth and Linneberg, Allan and Jarvelin, Marjo-Riitta and Noethen, Markus M. and Lau, Susanne and Hübner, Norbert and Lee, Young-Ae and Tamari, Mayum and Hinds, David A. and Glass, Daniel and Brown, Sara J. and Heinrich, Joachim and Evans, David M. and Weidinger, Stephan and EArly Genetics, and Lifecourse Epidemiology (EAGLE) Eczema Consortium, . (2015) Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nature Genetics, 47 (12). pp. 1449-1456.

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Official URL: https://edoc.unibas.ch/61576/

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Abstract

Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of <15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Human Genetics (Cichon)
UniBasel Contributors:Cichon, Sven
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
ISSN:1061-4036
e-ISSN:1546-1718
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Oct 2023 09:07
Deposited On:14 Sep 2018 18:05

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