Genome-wide association study reveals two new risk loci for bipolar disorder

Muhleisen, Thomas W. and Leber, Markus and Schulze, Thomas G. and Strohmaier, Jana and Degenhardt, Franziska and Treutlein, Jens and Mattheisen, Manuel and Forstner, Andreas J. and Schumacher, Johannes and Breuer, René and Meier, Sandra and Herms, Stefan and Hoffmann, Per and Lacour, André and Witt, Stephanie H. and Reif, Andreas and Müller-Myhsok, Bertram and Lucae, Susanne and Maier, Wolfgang and Schwarz, Markus and Vedder, Helmut and Kammerer-Ciernioch, Jutta and Pfennig, Andrea and Bauer, Michael and Hautzinger, Martin and Moebus, Susanne and Priebe, Lutz and Czerski, Piotr M. and Hauser, Joanna and Lissowska, Jolanta and Szeszenia-Dabrowska, Neonila and Brennan, Paul and McKay, James and Wright, Adam and Mitchell, Philip B and Fullerton, Janice M. and Schofield, Peter R. and Montgomery, Grant W. and Medland, Sarah E. and Gordon, Scott D. and Martin, Nicolas G. and Krasnow, Valery and Chuchalin, Alexander and Babadjanova, Gulja and Pantelejeva, Galina and Abramova, Lilia I. and Tiganov, Alexander S. and Polonikov, Alexey and Khusnutdinova, Elza and Alda, Martin and Grof, Paul and Rouleau, Guy A. and Turecki, Gustavo and Laprise, Catherine and Rivas, Fabio and Mayoral, Fermin and Kogevinas, Manolis and Grigoroiu-Serbanescu, Maria and Propping, Peter and Becker, Tim and Rietschel, Marcella and Nöthen, Markus M. and Cichon, Sven. (2014) Genome-wide association study reveals two new risk loci for bipolar disorder. Nat Commun, 5. p. 3339.

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Official URL: https://edoc.unibas.ch/61573/

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Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide association studies (GWAS) have robustly identified the first common genetic variants involved in disease aetiology. The data also provide strong evidence for the presence of multiple additional risk loci, each contributing a relatively small effect to BD susceptibility. Large samples are necessary to detect these risk loci. Here we present results from the largest BD GWAS to date by investigating 2.3 million single-nucleotide polymorphisms (SNPs) in a sample of 24,025 patients and controls. We detect 56 genome-wide significant SNPs in five chromosomal regions including previously reported risk loci ANK3, ODZ4 and TRANK1, as well as the risk locus ADCY2 (5p15.31) and a region between MIR2113 and POU3F2 (6q16.1). ADCY2 is a key enzyme in cAMP signalling and our finding provides new insights into the biological mechanisms involved in the development of BD.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Human Genetics (Cichon)
UniBasel Contributors:Cichon, Sven
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:2041-1723 (Electronic) 2041-1723 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:20 Jul 2020 14:55
Deposited On:20 Jul 2020 14:55

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