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Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease

Wollmer, M. Axel and Kapaki, Elisabeth and Hersberger, Martin and Muntwyler, Jörg and Brunner, Fabienne and Tsolaki, Magdalini and Akatsu, Hiroyasu and Kosaka, Kenji and Michikawa, Makoto and Molyva, Dimitra and Paraskevas, Giorgos P. and Lütjohann, Dieter and von Eckardstein, Arnold and Hock, Christoph and Nitsch, Roger M. and Papassotiropoulos, Andreas. (2006) Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease. American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol. 141B, H. 5. pp. 534-536.

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Official URL: http://edoc.unibas.ch/dok/A5257167

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Abstract

A recent study demonstrated a significant genetic association between the ATP-binding cassette transporter A2 (ABCA2) and the risk for Alzheimer's disease (AD) in a large Caucasian sample. The rare T allele of the synonymous exonic single nucleotide polymorphism (SNP) rs908832 was overrepresented in early-onset AD patients as compared to cognitively healthy controls. Here we confirm the association of rs908832 with AD in a Western European population (n = 291, P = 0.008). In a second sample from Southern Europe, rs908832 was not associated with AD. Interestingly, rs908832 was not polymorphic in a Japanese sample. Furthermore, rs908832 was not associated with either serum cholesterol levels or with the risk for coronary artery disease, but seemed to be related to cholesterol levels in the cerebrospinal fluid. These data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic AD and support a role of ABC lipid transporters in the pathogenesis of this disease.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-Liss
ISSN:1552-4841
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 06:39
Deposited On:22 Mar 2012 13:33

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