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Do cryptic reservoirs threaten gambiense-sleeping sickness elimination?

Informal Expert Group on Gambiense HAT Reservoirs, and Büscher, Philippe and Bart, Jean-Mathieu and Boelaert, Marleen and Bucheton, Bruno and Cecchi, Giuliano and Chitnis, Nakul and Courtin, David and Figueiredo, Luisa M. and Franco, José-Ramon and Grébaut, Pascal and Hasker, Epco and Ilboudo, Hamidou and Jamonneau, Vincent and Koffi, Mathurin and Lejon, Veerle and MacLeod, Annette and Masumu, Justin and Matovu, Enock and Mattioli, Raffaele and Noyes, Harry and Picado, Albert and Rock, Kat S. and Rotureau, Brice and Simo, Gustave and Thévenon, Sophie and Trindade, Sandra and Truc, Philippe and Van Reet, Nick. (2018) Do cryptic reservoirs threaten gambiense-sleeping sickness elimination? Trends in Parasitology, 34 (3). pp. 197-207.

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Abstract

Trypanosoma brucei gambiense causes human African trypanosomiasis (HAT). Between 1990 and 2015, almost 440000 cases were reported. Large-scale screening of populations at risk, drug donations, and efforts by national and international stakeholders have brought the epidemic under control with <2200 cases in 2016. The World Health Organization (WHO) has set the goals of gambiense-HAT elimination as a public health problem for 2020, and of interruption of transmission to humans for 2030. Latent human infections and possible animal reservoirs may challenge these goals. It remains largely unknown whether, and to what extend, they have an impact on gambiense-HAT transmission. We argue that a better understanding of the contribution of human and putative animal reservoirs to gambiense-HAT epidemiology is mandatory to inform elimination strategies.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Infectious Disease Modelling > Infectious Disease Modelling (Smith)
UniBasel Contributors:Chitnis, Nakul
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1471-4922
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:12 Jun 2018 08:55
Deposited On:08 Jun 2018 14:55

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