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Persistent organic pollutants in red- and white-blooded High-Antarctic notothenioid fish from the remote Weddell Sa

Strobel, Anneli and Schmid, Peter and Burkhardt-Holm, Patricia and Segner, Helmut and Zennegg, Markus. (2017) Persistent organic pollutants in red- and white-blooded High-Antarctic notothenioid fish from the remote Weddell Sa. Chemosphere, 193. pp. 213-222.

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Official URL: https://edoc.unibas.ch/61455/

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Abstract

The aryl hydrocarbon receptor (AhR) pathway mediates many, if not all, responses of fish to dioxin-like compounds. The Southern Ocean is progressively exposed to increasing concentrations of anthropogenic pollutants. Antarctic fish are known to accumulate those pollutants, yet nothing is known about their capability to induce chemical biotransformation via the AhR pathway. The objective of the present study was to investigate whether Antarctic eelpout, Pachycara brachycephalum, respond to anthropogenic pollutants by activation of the AhR and its target gene cytochrome P4501A (CYP1A), and of superoxide dismutase (SOD), which served as a representative for oxidative stress. We exposed P. brachycephalum to 10 and 100mg benzo[a]pyrene (BaP)/kg body weight for 10 d and measured the expression of AhR, CYP1A, and SOD in liver tissue via quantitative polymerase chain reaction. We identified two distinct AhR isoforms in the liver of P. brachycephalum. Antarctic eelpout responded to both BaP exposures by an up-regulation of AhR and SOD, and by a particularly strong induction of CYP1A expression, which remained high until day 10 of the exposure time. Our data suggest that P. brachycephalum possesses the potential to up-regulate xenobiotic biotransformation pathways, at least at the gene expression level. The time course of the AhR and CYP1A response points to an efficient but slow xenobiotics metabolism
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften > Integrative Biologie > Aquatische ├ľkologie (Holm)
UniBasel Contributors:Holm, Patricia
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0045-6535
e-ISSN:1879-1298
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:09 Sep 2020 10:05
Deposited On:09 Sep 2020 10:05

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