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The Rip1Tag2 Transgenic Mouse Model

Bill, Ruben and Christofori, Gerhard. (2016) The Rip1Tag2 Transgenic Mouse Model. Methods in Molecular Biology, 1464. pp. 151-161.

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Official URL: https://edoc.unibas.ch/61445/

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Abstract

The Rip1Tag2 transgenic mouse model of β-cell carcinogenesis has been instrumental in studying various aspects of tumor angiogenesis and in investigating the response to anti-angiogenic therapeutics. Thereby, the in-depth assessment of blood and lymphatic vessel phenotypes and functionality represents key experimental analyses. In this chapter, we describe basic protocols to assess tumor blood vessel morphology (pericyte coverage), functionality (perfusion, leakiness, and hypoxia), lymphatic tumor coverage, and tumor cell proliferation and apoptosis based on immunofluorescence microscopy analysis.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Biochemistry and Genetics > Tumor Biology (Christofori)
UniBasel Contributors:Christofori, Gerhard M.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer
ISSN:1064-3745
e-ISSN:1940-6029
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:20 Jan 2019 20:14
Deposited On:20 Jan 2019 20:14

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