Metformin Protects Auditory Hair Cells from Gentamicin-Induced Toxicity in vitro

Glutz, Andrea and Leitmeyer, Katharina and Setz, Cristian and Brand, Yves and Bodmer, Daniel. (2015) Metformin Protects Auditory Hair Cells from Gentamicin-Induced Toxicity in vitro. Audiology & Neurotology, 20 (6). pp. 360-369.

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Official URL: https://edoc.unibas.ch/61434/

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Metformin is a commonly used antidiabetic drug. It has been shown that this drug activates the AMP-activated protein kinase, which inhibits downstream the mammalian target of rapamycin. In addition, several studies indicate that metformin reduces intracellular reactive oxygen species. Our data, using an in vitro rat model, indicate that metformin is able to protect auditory hair cells (HCs) from gentamicin-induced apoptotic cell death. Moreover, metformin has no toxic effect on spiral ganglion neuronal survival or outgrowth in vitro. These results suggest a protective effect of metformin on auditory HC survival in gentamicin-induced HC loss in vitro.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Inner Ear Research (Bodmer)
UniBasel Contributors:Bodmer, Daniel K
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:11 Jul 2018 16:11
Deposited On:11 Jul 2018 16:11

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