Bidirectional GABAergic control of action potential firing in newborn hippocampal granule cells

Heigele, Stefanie and Sultan, Sébastien and Toni, Nicolas and Bischofberger, Josef. (2016) Bidirectional GABAergic control of action potential firing in newborn hippocampal granule cells. Nature Neuroscience, 19 (2). pp. 263-270.

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Official URL: https://edoc.unibas.ch/61419/

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Newly generated young neurons in the adult hippocampus receive GABAergic synaptic inputs, which are crucial for activity-dependent survival and functional maturation between 1-3 weeks after mitosis. We found synaptically driven action potential (AP) firing in these newborn young cells in adult mice. Although glutamatergic synaptic inputs remained subthreshold, activation of GABAergic synaptic inputs depolarized young neurons and reliably evoked APs. Furthermore, pairing of subthreshold excitatory postsynaptic potentials or somatic current injection with brief bursts of GABAergic inputs revealed efficient GABAergic excitation at conductances of approximately 1.5 nS, corresponding to the activity of only three or four interneurons. Stronger GABAergic inputs (<4 nS) effectively blocked AP firing via shunting inhibition, which might be important to dynamically control spiking output in both directions. Taken together, GABAergic interneurons differentially recruit newborn young granule cells by supporting either AP generation or shunting inhibition dependent on hippocampal network activity.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Physiology > Cellular Neurophysiology (Bischofberger)
UniBasel Contributors:Bischofberger, Josef
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1546-1726 (Electronic) 1097-6256 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Jan 2019 18:57
Deposited On:19 Jan 2019 18:57

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