Deletion of GABA-B receptor in Schwann cells regulates remak bundles and small nociceptive C-fibers

Faroni, Alessandro and Castelnovo, Luca Franco and Procacci, Patrizia and Caffino, Lucia and Fumagalli, Fabio and Melfi, Simona and Gambarotta, Giovanna and Bettler, Bernhard and Wrabetz, Lawrence and Magnaghi, Valerio. (2014) Deletion of GABA-B receptor in Schwann cells regulates remak bundles and small nociceptive C-fibers. Glia, 62 (4). pp. 548-565.

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Official URL: https://edoc.unibas.ch/61396/

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The mechanisms regulating the differentiation into non-myelinating Schwann cells is not completely understood. Recent evidence indicates that GABA-B receptors may regulate myelination and nociception in the peripheral nervous system. GABA-B receptor total knock-out mice exhibit morphological and molecular changes in peripheral myelin. The number of small myelinated fibers is higher and associated with altered pain sensitivity. Herein, we analyzed whether these changes may be produced by a specific deletion of GABA-B receptors in Schwann cells. The conditional mice (P0-GABA-B1(fl/fl)) show a morphological phenotype characterized by a peculiar increase in the number of small unmyelinated fibers and Remak bundles, including nociceptive C-fibers. The P0-GABA-B1(fl/fl) mice are hyperalgesic and allodynic. In these mice, the morphological and behavioral changes are associated with a downregulation of neuregulin 1 expression in nerves. Our findings suggest that the altered pain sensitivity derives from a Schwann cell-specific loss of GABA-B receptor functions, pointing to a role for GABA-B receptors in the regulation of Schwann cell maturation towards the non-myelinating phenotype.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Physiology > Molecular Neurobiology Synaptic Plasticity (Bettler)
UniBasel Contributors:Bettler, Bernhard
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley Liss
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 Jul 2020 13:49
Deposited On:17 Jul 2020 07:55

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