HLA-C levels impact natural killer cell subset distribution and function

Sips, Magdalena and Liu, Qingquan and Draghi, Monia and Ghebremichael, Musie and Berger, Christoph T. and Suscovich, Todd J. and Sun, Yongtao and Walker, Bruce D. and Carrington, Mary and Altfeld, Marcus and Brouckaert, Peter and De Jager, Philip L. and Alter, Galit. (2016) HLA-C levels impact natural killer cell subset distribution and function. Human Immunology, 77 (12). pp. 1147-1153.

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Official URL: https://edoc.unibas.ch/61293/

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Differences in HLA-C expression are inversely correlated with HIV viral load set-point and slower progression to AIDS, linked to enhanced cytotoxic T cell immunity. Yet, beyond T cells, HLA-C serves as a dominant ligand for natural killer (NK) cell killer immunoglobulin-like receptors (KIR). Thus, we speculated that HLA-C expression levels may also impact NK activity, thereby modulating HIV antiviral control. Phenotypic and functional profiling was performed on freshly isolated PBMCs. HLA-C expression was linked to changes in NK subset distribution and licensing, particularly in HLA-C1/C1, KIR2DL3+2DL2-individuals. Moreover, high levels of HLA-C, were associated with reduced frequencies of anergic CD56neg NKs and lower frequencies of KIR2DL1/2/3+ NK cells, pointing to an HLA-C induced influence on the NK cell development in the absence of disease. In HIV infection, several spontaneous controllers, that expressed higher levels of HLA-C demonstrated robust NK-IFN-γ secretion in response to target cells, highlighting a second disease induced licensing phenotype. Thus this population study points to a potential role for HLA-C levels both in NK cell education and development.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Translational Immunology (Berger)
UniBasel Contributors:Berger, Christoph T.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Jan 2019 17:44
Deposited On:22 Jan 2019 17:44

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