The troika host-pathogen-extrinsic factors in Tuberculosis: modulating inflammation and clinical outcomes

Bastos, Helder Novais and Osório, Nuno S. and Gagneux, Sebastien and Comas, Iñaki and Saraiva, Margarida. (2018) The troika host-pathogen-extrinsic factors in Tuberculosis: modulating inflammation and clinical outcomes. Frontiers in Immunology, 8. p. 1948.

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The already enormous burden caused by tuberculosis (TB) will be further aggravated by the association of this disease with modern epidemics, as human immunodeficiency virus and diabetes. Furthermore, the increasingly aging population and the wider use of suppressive immune therapies hold the potential to enhance the incidence of TB. New preventive and therapeutic strategies based on recent advances on our understanding of TB are thus needed. In particular, understanding the intricate network of events modulating inflammation in TB will help to build more effective vaccines and host-directed therapies to stop TB. This review integrates the impact of host, pathogen, and extrinsic factors on inflammation and the almost scientifically unexplored complexity emerging from the interactions between these three factors. We highlight the exciting data showing a contribution of this; troika; for the clinical outcome of TB and the need of incorporating it when developing novel strategies to rewire the immune response in TB.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Gagneux, Sebastien
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Frontiers Media
Note:Publication type according to Uni Basel Research Database: Journal article
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edoc DOI:
Last Modified:14 Sep 2018 12:55
Deposited On:27 Jun 2018 09:49

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