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Split for the cure: VEGF, PDGF-BB and intussusception in therapeutic angiogenesis

Gianni-Barrera, Roberto and Bartolomeo, Mariateresa and Vollmar, Brigitte and Djonov, Valentin and Banfi, Andrea. (2014) Split for the cure: VEGF, PDGF-BB and intussusception in therapeutic angiogenesis. Biochemical Society Transactions, 42 (6). pp. 1637-1642.

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Official URL: https://edoc.unibas.ch/61123/

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Abstract

Therapeutic angiogenesis is an attractive strategy to treat patients suffering from ischaemic conditions and vascular endothelial growth factor-A (VEGF) is the master regulator of blood vessel growth. However, VEGF can induce either normal or aberrant angiogenesis depending on its dose localized in the microenvironment around each producing cell in vivo and on the balanced stimulation of platelet-derived growth factor-BB (PDGF-BB) signalling, responsible for pericyte recruitment. At the doses required to induce therapeutic benefit, VEGF causes new vascular growth essentially without sprouting, but rather through the alternative process of intussusception, or vascular splitting. In the present article, we briefly review the therapeutic implications of controlling VEGF dose on one hand and pericyte recruitment on the other, as well as the key features of intussusceptive angiogenesis and its regulation.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Cell and Gene Therapy (Banfi)
UniBasel Contributors:Banfi, Andrea
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Portland Press
ISSN:0300-5127
e-ISSN:1470-8752
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Language:English
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Last Modified:08 Oct 2018 13:20
Deposited On:16 Mar 2018 15:02

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