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Human migration and the spread of malaria parasites to the New World

Rodrigues, Priscila T. and Valdivia, Hugo O. and de Oliveira, Thais C. and Alves, João Marcelo P. and Duarte, Ana Maria R. C. and Cerutti-Junior, Crispim and Buery, Julyana C. and Brito, Cristiana F. A. and de Souza, Júlio César and Hirano, Zelinda M. B. and Bueno, Marina G. and Catão-Dias, José Luiz and Malafronte, Rosely S. and Ladeia-Andrade, Simone and Mita, Toshihiro and Santamaria, Ana Maria and Calzada, José E. and Tantular, Indah S. and Kawamoto, Fumihiko and Raijmakers, Leonie R. J. and Mueller, Ivo and Pacheco, M. Andreina and Escalante, Ananias A. and Felger, Ingrid and Ferreira, Marcelo U.. (2018) Human migration and the spread of malaria parasites to the New World. Scientific reports, 8 (1). p. 1993.

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Abstract

We examined the mitogenomes of a large global collection of human malaria parasites to explore how and when Plasmodium falciparum and P. vivax entered the Americas. We found evidence of a significant contribution of African and South Asian lineages to present-day New World malaria parasites with additional P. vivax lineages appearing to originate from Melanesia that were putatively carried by the Australasian peoples who contributed genes to Native Americans. Importantly, mitochondrial lineages of the P. vivax-like species P. simium are shared by platyrrhine monkeys and humans in the Atlantic Forest ecosystem, but not across the Amazon, which most likely resulted from one or a few recent human-to-monkey transfers. While enslaved Africans were likely the main carriers of P. falciparum mitochondrial lineages into the Americas after the conquest, additional parasites carried by Australasian peoples in pre-Columbian times may have contributed to the extensive diversity of extant local populations of P. vivax.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Molecular Diagnostics (Felger)
UniBasel Contributors:Felger, Ingrid
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer Nature
ISSN:0169-5487
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:26 Apr 2019 15:27
Deposited On:25 Jun 2018 13:26

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