Medication adherence assessment: high accuracy of the new Ingestible Sensor System in kidney transplants

Eisenberger, Ute and Wüthrich, Rudolf P. and Bock, Andreas and Ambühl, Patrice and Steiger, Jürg and Intondi, Allison and Kuranoff, Susan and Maier, Thomas and Green, Damian and DiCarlo, Lorenzo and Feutren, Gilles and De Geest, Sabina. (2013) Medication adherence assessment: high accuracy of the new Ingestible Sensor System in kidney transplants. Transplantation, 96 (3). pp. 245-250.

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Official URL: https://edoc.unibas.ch/60844/

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This open-label single-arm exploratory study evaluated the accuracy of the Ingestible Sensor System (ISS), a novel technology for directly assessing the ingestion of oral medications and treatment adherence.; ISS consists of an ingestible event marker (IEM), a microsensor that becomes activated in gastric fluid, and an adhesive personal monitor (APM) that detects IEM activation. In this study, the IEM was combined to enteric-coated mycophenolate sodium (ECMPS). Twenty stable adult kidney transplants received IEM-ECMPS for a mean of 9.2 weeks totaling 1227 cumulative days.; Eight patients prematurely discontinued treatment due to ECMPS gastrointestinal symptoms (n=2), skin intolerance to APM (n=2), and insufficient system usability (n=4). Rash or erythema due to APM was reported in 7 (37%) patients, all during the first month of use. No serious or severe adverse events and no rejection episode were reported. IEM detection accuracy was 100% over 34 directly observed ingestions; Taking Adherence was 99.4% over a total of 2824 prescribed IEM-ECMPS ingestions. ISS could detect accurately the ingestion of two IEM-ECMPS capsules taken at the same time (detection rate of 99.3%, n=2376).; ISS is a promising new technology that provides highly reliable measurements of intake and timing of intake of drugs that are combined with the IEM.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Institut für Pflegewissenschaft
UniBasel Contributors:De Geest, Sabina M.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott Williams & Wilkins
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Jul 2020 12:59
Deposited On:16 Jul 2020 12:59

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